Uyama H, Yamauchi M, Fujita Y, Yoshikawa M, Ohnishi Y, Kimura H. The effects of accompanying arousal to apneic event on blood pressure and sympathetic nerve activity in severe obstructive sleep apnea. Sleep Breath. 2018;22:149-155.



Yoshikawa M, Yamamoto Y, Tomoda K, Fujita Y, Yamauchi M, Osa T, Uyama H, Okamoto N, Kurumatani N, Kimura H. Prevalence of chronic obstructive pulmonary disease in independent community- dwelling elderly. The Fujiwara-kyo Study. Geriatr Gerontol Int. 2017;17:2421-2426.

Smid DE, Franssen FME, Kimura H, Yoshikawa M, et al. Redefining cut-points for high symptom burden of the Global Initiative for Chronic Obstructive Lung Disease classification in 18,577 patients with chronic obstructive pulmonary disrase. J Am Med Dir Assoc. 2017;18(12): 1097.e11- 1097.e24.

Kai Y, Tomoda K, Yoneyama H, Kitabatake M, Nakamura A, Ito T, Yoshikawa M, Kimura H. Silencing of carbohydrate sulfotransferase 15 hinders murine pulmonary fibrosis development. Mol Ther Nucleic Acids. 2017;6:163-172.

Fujita Y, Yamauchi M, Uyama H, Kumamoto M, Koyama N, Yoshikawa M, Strohl KP, Kimura H. Variability of breathing during wakefulness while using CPAP predicts adherence. Respirology. 2017; 22: 386-393.

Tohda Y, Iwanaga T, Sano H, Kume H, Hirata K, Ohkura N, Tachibana I, Nishimura Y, Matsumoto H, Minakata Y, Yoshikawa M, Fujimura M. Improved quality of life in asthma patients under long-term therapy: Assessed by AHQ-Japan. Int J Clin Pract. 2017;71:e12898.



Koguchi N, Okada A, Choh S, Katayama K, Takenaka H, Tomoda K, Kimura H:Concomitant Systemic Sclerosis and Sarcoidosis with Combined Pulmonary Fibrosis and Emphysema. Intern Med. 2016;55:1331-1335.

Fujita Y, Yamauchi M, Uyama H, Kumamoto M, Koyama N, Yoshikawa M, Strohl KP, Kimura H:Variability of breathing during wakefulness while using CPAP predicts adherence. Respirology. 2016 (in press)

Yamauchi M, Combs D, Parthasarathy S. Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure:N Engl J Med. 2016;374:689.

Strohl KP, Baskin JZ, Lance C, Ponsky D, Weidenbecher M, Strohl M, Yamauchi M:Origins of and implementation concepts for upper airway stimulation therapy for obstructive sleep apnea. Respiratory Investigation. 2016;54:241-249.

Kumamoto M, Tomoda K, Furuya Y, Iwasa N, Ueno S, Yoshikawa M, Kimura H:Hypertrophic pachymeningitis as a delayed complication of granulomatosis with polyangiitis. Intern Med. 2016;55:413-417.

Ota M, Mochizuki S, Shimoda M, Abe H, Miyamae Y, Ishii K, Kimura H, Okada Y:ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells. Cancer Sci. 2016;107:433-443.



Kai Y, Tomoda K, Yoneyama H, Yoshikawa M, Kimura H:RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. Respir Res. 2015;16(1):146.

Iwai K, Tomoda K, Nakai T, Kimura H:A Hypopharyngeal Lipoma Resulting in Obstructive Sleep Apnea. Intern Med. 2015;54(21):2789-2790.

Yamauchi M, Fujita Y, Kumamoto M, Yoshikawa M, Ohnishi Y, Nakano H, Strohl KP, Kimura H:Nonrapid Eye Movement-Predominant Obstructive Sleep Apnea: Detection and Mechanism. J Clin Sleep Med. 2015;11:987-993.

Katayama K, Tomoda K, Ohya T, Asada H, Ohbayashi C, Kimura H:Ground-glass opacities and a solitary nodule on chest in intravascular large B-cell lymphoma. Respirology Case Reports. 2015;3:108-111.

Tomoda K, Kubo K, Dairiki K, Yamaji T, Yamamoto Y, Nishii Y, Nakamura A, Yoshikawa M, Hamada K, Kimura H:Whey peptide-based enteral diet attenuate elastase-induced emphysema with increase in short chain fatty acids in mice. BMC pulm Med. 2015;15:64 DOI 10.1186/s12890-015-0059-2.

Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K:Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung. 2015;193:239-247.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Takamura K, Hanaoka M, Nishimura M, TatsumiK, the JRS Lung Disease PH Study Group:Multi-institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseases. Respirology. 2015; 20:805-812.

Miura S, Ohno Y, Kimura H, Kichikawa K:Quantitative lung perfused blood volume imaging on dual-energy CT: capability for quantitative assessment of disease severity in patients with acute pulmonary thromboembolism. Acta Radiol. 2015; 56:284-293.



Decker M, Yamauchi M, Strohl KP:Keep the airway open and let the brain sleep. Am J Respir Crit Care Med. 2014;190:1207-1209.

Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, Sakai C, Itoh M, Sato GE, Hashimoto A, Fujita M, Okumura K, Araki M, Xin M, Pedersen RA, Utset MF, Kimura H, Nakagawa O:An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014;52(11):897-906.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Miyaji K, Takamura K, Hayashi S, Hanaoka M, Tatsumi K:Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society. Respir Invest. 2014;52:167-172.

Tomoda K, Kubo K, Hino K, Kondoh Y, Nishii Y, Koyama N, Yamamoto Y, Yoshikawa M, Kimura H:Branched-chain amino acid-rich diet improves skeletal muscle wasting caused by cigarette smoke in rats. J Toxicol Sci. 2014;39(2):331-337.

Yoshikawa M, Fujita Y, Yamamoto Y, Yamauchi M, Tomoda K, Koyama N, Kimura H: The Mini Nutritional Assessment Short-form predicts exacerbation frequency in patients with chronic obstructive pulmonary disease. Respirology. 2014;19(8):1198-1203.

Yamauchi M, Jacono FJ, Fujita Y, Kumamoto M, Yoshikawa M, Campanaro CK, Loparo KA, Strohl KP, Kimura H:Effects of environment light during sleep on autonomic functions of heart rate and breathing. Sleep Breath. 2014; 18:829-835.

Uno K, Kasahara K, Kutsuna S, Katanami Y, Yamamoto Y, Maeda K, Konishi M, Ogawa T, Yoneda T, Yoshida K, Kimura H, Mikasa K: Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient. J Infact Chemother. 2014; 20:131-133.

Yamamoto Y, Yoshikawa M, Tomoda K, Fujita Y, Yamauchi M, Fukuoka A, Tamaki S, Koyama N, Kimura H: Distribution of bone mineral content is associated with body weight and exercise capacity in patients with COPD. Respiration. 2014;87:158-164.

Yamauchi M, Jacono FJ, Fujita Y, Kumamoto M, Yoshikawa M, Campanaro CK, Loparo KA, Strohl KP, Kimura H: Effects of environment light during sleep on autonomic functions of heart rate and breathing. Sleep And Breathing. 2014;18(4):829-835.

Yoshikawa M, Yamauchi M, Fujita Y, Koyama N, Fukuoka A, Tamaki S, Yamamoto Y, Tomoda K, Kimura H: The Impact of Obstructive Sleep Apnea and Nasal CPAP on Circulating Adiponectin Levels. Lung. 2014;192(2):289-295.

Ramsey R, Khanna A, Yamauchi M, Clinical Evaluations of the Patient. In: Strohl KP, ed:Competencies in Sleep Medicine -An Assessment Guide-: Springer New York. 2014;109-127.



Tomoda K, Kimura H, Osaki S:Distribution of collagen fiber orientation in the human lung. Anat Rec (Hoboken). 2013;296(5):846-850.

Yamauchi M, Jacono FJ, Fujita Y, Yoshikawa M, Ohnishi Y, Nakano H, Campanaro CK, Loparo KA, Strohl KP, Kimura H:Breathing irregularity during wakefulness associated with CPAP acceptance in sleep apnea. Sleep Breath.2013;17(2):845-852.

NakamuraA, Nagaya N, Obata H, Sakai K, Sakai Y, Yoshikawa M, Hamada K, Matsumoto K, Kimura H:Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension.Circ J.2013;77(8):2127-2133.

Kyotani Y, Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Zhao J, Ozawa K, Nagayama K, Ito S, Takasawa S, Kimura H, Uno M, Yoshizumi M:Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor.Exp Cell Res. 2013;319:3042-3050.

Ota H, Itaya-Hironaka S, Yamauchi A, Sakuramoto-Tsuchida S, Miyaoka T, Fujimura T, Tsujinaka H, Yoshimoto K, Nakagawara K, Tamaki S, Takasawa S, Kimura H:Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene.Life Sci. 2013;93:664-672.



Gillombardo CB, Yamauchi M, Adams MD, Dostal J, Chai S, Moore MW, Donovan LM, Han F, Strohl KP:Identification of novel mouse genes conferring posthypoxic pauses. J Appl Physiol. 2012; 113:167-174.

Yamauchi M, Strohl KP:A 20-year-old man with morning headache, excessive daytime sleepiness, heavy snoring, and apnea during sleep. In: Basner RC, ed. Case Studies in Polysomnography Interpretation: Cambridge University Press, 2012:137.

Morita K, Nakamine H, Inoue R, Takano M, Takeda M, Enomoto Y, Kasai T, Nonomura A, Tanaka H, Amano I, Morii T, Kimura H:Autopsy case of primary myelofibrosis in which myeloid sarcoma was the initial manifestation of tumor progression. Pathol Int.2012;62(6):433-437.

Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K:Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial.PLoS One. 2012; 7:e35708.

Tomoda K, Kubo K, Asahara T, Nomoto K, Nishii Y, Yamamoto Y, Yoshikawa M, Kimura H:Suppressed anti-oxidant capacity due to a cellulose-free diet declines further by cigarette smoke in mice. J Toxicol Sci. 2012;37:575-585.

Hasegawa K, K Kimura H, Bando YK, Takahashi Y, Wada H, Fujita M:Tobacco, Cardiopulmonary Vascular Disease, and Aging. Anti-aging Medicine. 2012;9:51-60.

Koyama N, Matsumoto M, Tamaki S, Yoshikawa M, Fujimura Y, Kimura H:Reduced larger VWF multimers at dawn in OSA plasmas reflect severity of apneic episodes. Eur Respir J. 2012;40:657-664.

Okada H, Hontsu S, Miura S, Asakawa I, Tamamoto T, Katayama E, Iwasaki S, Kimura H, Kichikawa K, Hasegawa M:Changes of tumor size and tumor contrast enhancement during radiothrapy for non-small-cell lung cancer may be suggestive of treatment response. J Radia Res. 2012;53:326-332.

Ota H, Tamaki S, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S, Kimura H:Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci. 2012;90:206-211.

Tomoda K, Kubo K, Nishii Y, Yamamoto Y, Yoshikawa M, Kimura H:Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats. J Toxicol Sci. 2012;37:131-138.

Tomita K, Sano H, Iwanaga T, Ishihara K, Ichinose M, Kawase I, Kimura H, Hirata K, Fujimura M, Mishima M, Tohda Y:Association between episodes of upper respiratory infection and exacerbations in adult patients with asthma. J Asthma. 2012;49:253-259.



Yamauchi M, Tamaki S, Yoshikawa M, Ohnishi Y, Nakano H, Jacono FJ, Loparo KA, Strohl KP, Kimura H:Differences in breathing patterning during wakefulness in patients with mixed apnea-dominant vs obstructive-dominant sleep apnea. Chest.2011;140:54-61.

Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N:Alkbh3, a human alkb homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer. 2011;104:700-706.

Tomoda K, Kubo K, Asahara T, Andoh A, Nomoto K, Nishii Y, Yamamoto Y, Yoshikawa M, Kimura H:Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats. J Toxicol Sci. 2011;36:261-266.

Maruyama H, Toyoda- Hirana Y, Nakamura T, Enomoto Y, Hamada K, Kimura H:An autopsy case of porto- pulmonary hypertension associated with alcoholic liver cirrhosis. Journal of Nara Medical Association. 2011;62:81-87.

Yoshikawa M, Koyama N, Hontsu S, Yamamoto Y, Mikasa K, Kimura H:Lessons from eight cases of adult pulmonary toxocariasis: abridged republication. Respirology.2011;16:1014-1015.



Yamauchi M, Kimura H, Strohl KP:Mouse models of apnea:strain differences in apnea expression and its pharmacologic and genetic modification. Adv Exp Med Biol.2010;669:303-307.

Kimura H, Toga H, Yamaya M, Mishima M, Nukiwa T, Kudo S:Current Situations and Issues in Respiratory Medicine in Japan. Japan Medical Association Journal.2010:53:178-184.



Tamaki S, Yamauchi M, Fukuoka A, Makinodan K, Koyama N, Tomoda K, Yoshikawa M, Kimura H:Production of inflammatory mediators by monocytes in patients with obstructive sleep apnea syndrome. Intern Med. 2009;48:1255-1262.

Kumamoto M, Nishiwaki T, Matsuo N, Kimura H, Matsushima K:Minimally-cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury. Eur Respir J.2009;34:740-748.

Tamaki S, Yamauchi M, Fukuoka A, Makinodan K, Koyama N, Tomoda K, Yoshikawa M, Kimura H:Nocturnal hypoxic stress activates invasive ability of monocytes in patients with obstructive sleep apnoea syndrome. Respirology. 2009;14:689-694.

Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kimura H, Ohi M, Fukuhara S:Simple four-variable screening tool for identification of patients with sleep-disordered breathing. Sleep. 2009;32:939-948.

Yamamoto Y, Konoike Y, Nakamine H, Nakamura S, Morii T, Kimura H:Multiple myeloma with a variant Burkitt-type translocation, t(2;8)(p12;q24), associated with hyperammonemia. Intern Med. 2009;48:1239-1242.



Yamauchi M, Ocak H, Dostal J, Jacono FJ, Loparo KA, Strohl KP:Post-sigh breathing behavior and spontaneous pauses in the C57BL/6J (B6) mouse. Respir Physiol Neurobiol. 2008; 162:117-125.

Yamauchi M, Dostal J, Strohl KP:Post-hypoxic unstable breathing in the C57BL/6J mouse: effects of acetazolamide. Adv Exp Med Biol. 2008; 605:75-79.

Makinodan K, Itoh T, Tomoda K, Tamaki S, Koyama N, Yoshikawa M, Hamada K, Kimura H:Acute pulmonary thromboembolism associated with interstitial pneumonia. Intern Med. 2008,47:647-650.

Yamauchi M, Dostal J, Kimura H, Strohl KP:Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains. J Appl Physiol. 2008, 105:518-526.

Yamauchi M, Kimura H:Oxidative stress in obstructive sleep apnea: putative pathways to the cardiovascular complications. Antioxid Redox Signal. 2008, 10:755-768.

Kitamura K, Asada H, Iida H, Fukumoto T, Kobayashi N, Niizeki H, Morii T, Kimura H, Miyagawa S:Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogenic stem cell transplantation. J Am Acad Dermatol. 2008, 58:802-809.

Suzaki Y, Hamada K, Nomi T, Ito T, Sho M, Kai Y, Nakajima Y, Kimura H:A small-molecule compound targeting CCR5 and CXCR3 prevents the development of asthma. Eur Respir J. 2008, 31:783-789.

Makinodan K, Yoshikawa M, Fukuoka A, Tamaki S, Koyama N, Yamauchi M, Tomoda K, Hamada K, Kimura H:Effect of serum leptin levels on hypercapnic ventilatory response in obstructive sleep apnea. Respiration. 2008, 75:257-264.



Yamauchi M, Han F, Strohl KP:Apnea and irregular breathing in animal models: a physiogenomic approach. In: Gaultier C, ed. Genetic Basis for Respiratory Control Disorders New York: Springer. 2007; 137-151.

Yamauchi M, Dostal J, Strohl KP:Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse. J Appl Physiol. 2007; 103:1263-1268.

Strohl KP, Yamauchi M, Dick TE:Loop Gain and Sleep Disordered Breathing Current Respiratory Medicine Reviews. 2007; 3:85-92.

Kai Y, Yoneyama H, Koyama J, Hamada K, Kimura H, Matsushima K:Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis. Med Mol Morphol. 2007, 40:128-140.

Tomoda K, Yoshikawa M, Itoh T, Tamaki S, Fukuoka A, Komeda K, Kimura H:Elevated circulating plasma adiponectin in underweight patients with COPD. Chest. 2007, 132:135-140.

Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N:Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2007, 293:L446-452.

Takeda M, Arao T, Yokote H, Komatsu T, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K:AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin Cancer Res. 2007, 13:3051-3057.

Hamada K, Suzaki Y, Leme A, Ito T, Miyamoto K, Kobzik L, Kimura H:Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A. 2007, 70:688-695.

Miyawaki S, Kawai Y, Takeshita A, Komatsu N, Usui N, Arai Y, Ishida F, Morii T, Kano Y, Ogura M, Doki N, Ohno R:Phase I trial of flagm with high doses of cytosine arabinoside for relapsed, refractory acute myeloid leukemia: study of the Japan Adult Leukemia Study Group (JALSG). Int J Hematol. 2007, 86:343-347.

Yanada M, Jinnai I, Takeuchi J, Ueda T, Miyawaki S, Tsuzuki M, Hatta Y, Usui N, Wada H, Morii T, Matsuda M, Kiyoi H, Okada M, Honda S, Miyazaki Y, Ohno R, Naoe T:Clinical features and outcome of t-lineage acute lymphoblastic leukemia in adults: a low initial white blood cell count, as well as a high count predict decreased survival rates. Leuk Res. 2007, 31:907-914.



Miyamoto K, Iwase M, Nyui M, Arata S, Sakai Y, Gabazza EC, Kimura H, Homma I:Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model. Int Arch Allergy Immunol. 2006;140:215-222.

Yamauchi M, Tamaki S, Tomoda K, Yoshikawa M, Fukuoka A, Makinodan K, Koyama N, Suzuki T, Kimura H:Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. Sleep Breath. 2006, 10:189-193.

Murakami S, Kimura H, Kangawa K, Nagaya N:Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension. Cardiovasc Hematol Disord Drug Targets. 2006, 6:125-132.

Itoh T, Nagaya N, Ishibashi-Ueda H, Kyotani S, Oya H, Sakamaki F, Kimura H, Nakanishi N:Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension. Respirology. 2006, 11:158-163.

Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H:Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2006, 290:L59-65.



Murakami S, Nagaya N, Itoh T, Iwase T, Fujusato T, Nishioka K, Hamada K, Kangawa K, Kimura H:Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med. 2005, 172 :581-589.

Yamauchi M, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Suzuki T, Kimura H:Oxidative stress in obstructive sleep apnea. Chest. 2005, 127:1674-1679.

Suzaki Y, Hamada K, Sho M, Ito T, Miyamoto K, Akashi S, Kashizuka H, Ikeda N, Nakajima Y, Iwase M, Homma I, Kobzik L, Kimura H:A potent anti-angiogenic factor, endostatin prevents the development of asthma in a murine model. J Allergy Clin Immunol. 2005, 116:1220-1227.

Fujita Y, Kasahara K, Uno K, Konishi M, Maeda K, Yoshimoto E, Murakawa K, Mikasa K, Amano I, Morii T, Kimura H:Amphotericin B-induced nephrogenic diabetes insipidus in a case of cryptococcemia. Intern Med. 2005, 44: 458-461.

Ito T, Hamada K, Suzaki Y, Matsui N, Kita E, Kimura H:Subcutaneous vaccination Mycobacterium bovis bacillus Calmette-Gue´rin attenuates allergic inflammation in a murine model of asthma. Allergology International. 2005, 54:601-609.

Kasahara K, Kita E, Maeda K, Uno K, Konishi M, Yoshimoto E, Murakawa K, Mikasa K, Kimura H:Macrolide resistance of Streptococcus pneumoniae isolated during long-term macrolide therapy: difference between erythromycin and clarithromycin. J Infect Chemother. 2005, 11:112-114.

Kasahara K, Maeda K, Mikasa K, Uno K, Takahashi K, Konishi M, Yoshimoto E, Murakawa K, Kita E, Kimura H:Clonal dissemination of macrolide-resistant and penicillin-susceptible serotype 3 and penicillin-resistant taiwan 19F-14 and 23F-15 streptococcus pneumoniae isolates in japan: a pilot surveillance study. J ClinMicrobiol. ,2005, 43:1640-1645.

Kasahara K, Fukuoka A, Murakawa K, Okamura H, Mikasa K, Narita N, Kimura H:Tuberculous peritonitis developing during chemotherapy for pulmonary and intestinal tuberculosis: a case report. Respirology. 2005, 10:257-260.

Yoneda K, Morii T, Nieda M, Tsukaguchi N, Amano I, Tanaka H, Yagi H, Narita N, Kimura H:The peripheral blood valpha24+ nkt cell numbers decrease in patients with haematopoietic malignancy. LeukRes. 2005, 29:147-152.

Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y:Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res. 2005, 11:2947-2953.

Kuzumoto Y, Sho M, Ikeda N, Mizuno T, Hamada K, Akashi S, Tsurui Y, Kashizuka H, Nomi T, Kanehiro H, Nakajima Y:Role of Ep4 prostaglandin E2 receptor in the ischemic liver. Transplant Proc. 2005, 37:422-424.

Akadegawa K, Ishikawa S, Sato T, Suzuki J, Yurino H, Kitabatake M, Ito T, Kuriyama T: Matsushima K:Breakdown of mucosal immunity in the gut and resultant systemic sensitization by oral antigens in a murine model for systemic lupus erythematosus. J Immunol. 174: 5499-5506, 2005.

Hanabusa K, Nagaya N, Iwase T, Itoh T, Murakami S, Shimizu Y, Taki W, Miyatake K, Kangawa K:Adrenomedullin enhances therapeutic potency of mesenchymal stem cells after experimental stroke in rats. Stroke. 2005, 36: 853-858.

Iwase T, Nagaya N, Fujii T, Itoh T, Ishibashi-Ueda H, Yamagishi M, Miyatake K, Matsumoto T, Kitamura S, Kangawa K:Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Circulation.2005, 111: 356-362.

Fujii T, Nagaya N, Iwase T, Murakami S, Miyahara Y, Nishigami K, Ishibashi-Ueda H, Shirai M, Itoh T, Ishino K, Sano S, Kangawa K, Mori H:Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats. Am J Physiol Heart Circ Physiol. 2005, 288: H1444-450.

Furukoji E. Matsumoto M, Yamashita A, Yagi H, Sakurai Y, Marutsuka K, Hatakeyama K, Morishita K, Fujimura Y, Tamura S, Asada Y:Adenovirus-mediated transfer of human placental ecto-ATP diphosphohydrolase I to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo. Circulation.2005, 111: 808-815.

Fujisaki K, Matsutani K, Yoshimitsu T, Nakanishi K, Matsumoto M, Yagi H, Ishizashi H, Fujimura Y, Takeda K, Hirakata H, Iida M:Thrombotic thrombocytopenic purpura associated with polyarthritisnodosa: demonstration of the inhibitor against von Willebrand factor-cleaving protease. Clinical Nephrol. 2005, 64:305-310.

Matsumoto M, Kawaguchi S, Ishizashi H, Yagi H, Iida J, Sakaki T, Fujimura Y:Platelets treated with ticlopidine are less reactive to unusually large VWF multimers than are those treated with aspirin under high shear stress. Pathophy Haemost Thromb.2005, 34:35-40.



Itoh T, Nagaya N, Fujii T, Iwase T, Nakanishi N, Hamada K, Kangawa K, Kimura H:A combination of oral sildenanafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med. 2004, 169: 34-38.

Itoh T, Nagaya N, Yoshikawa M, Fukuoka A, Takenaka H, Shimizu Y, Haruta Y, Oya H, Yamagishi M, Hosoda H, Kangawa K, Kimura H:Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004, 170: 870-878.

Suzuki T, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Yamauchi M, Kimura H:Obstructive sleep apnea and carotid artery intima-media thickness. Sleep. 2004, 27: 129-133.

Kasahara K, Maeda K, Mikasa K, Uno K, Takahashi K, Konishi M, Yoshimoto E, Murakawa K, Kita E, Kimura H:Long term azithromycin therapy for three patients with chronic lower respiratory tract infections. J Infect Chemother. 2004, 10: 42-45.

Yamamoto Y, Tsujimoto M, Konoike Y, Nakamine H, Morii T, Kimura H:Richter’s syndrome presenting as a nasal lymphoma. Leuk Lymphoma. 2004, 45: 1919-1923.

Yamamoto Y, Morii T, Kimura H:Paralytic ileus occurring during treatment with all-trans retinoic acid for acute promyelocytic leukemia. Int J Hematol. 2004, 79: 198-199.

Itoh T, Nagaya N, Murakami S, Fujii T, Iwase T, Ishibashi-Ueda H, Yutani C, Yamagishi M, Kimura H, Kangawa K:C-Type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats. Am J RespirCrit Care Med. 2004, 170: 1204-1211.

Miyamoto K, Iwase M, Kimura H, Homma I:Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice. Respir Physiol Neurobiol.2004, 144:25-33.

Ito T, Ishikawa S, Sato T, Akadegawa K, Yurino H, Kitabatake M, Hontsu S, Ezaki T, Kimura H, Matsushima K:Defective B1 cell homing to the peritoneal cavity and preferential recruitment of b1 cells in the target organs in a murine model for systemic lupus erythematosus. J Immunol. 2004, 172: 3628-3634.

Hontsu S, Yoneyama H, Ueha S, Terashima Y, Kitabatake M, Nakano A, Ito T, Kimura H, Matsushima K:Visualization of naturally occurring Foxp3+ regulatory T cells in normal and tumor-bearing mice. Int Immunopharmacol. 2004, 4: 1785-1793.

Murakami S, Nagaya N, Itoh T, Fujii T, Iwase T, Hamada K, Kimura H, Kangawa K:C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2004, 287: L1172-1177.

Nishiwaki T, Yoneyama H, Eishi Y, Matsuo N, Tatsumi K, Kimura H, Kuriyama T, Matsushima K:Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. Am J Pathol. 2004, 165: 631-639.

Sato T, Ishikawa S, Akadegawa K, Ito T, Yurino H, Kitabatake M, Yoneyama H, Matsushima K:Aberrant B1 cell migration into the thymus results in activation of CD4 T cells through its potent antigen-presenting activity in the development of murine lupus. Eur J Immunol. 2004, 34: 3346-3358.

Yurino H, Ishikawa S, Sato T, Akadegawa K, Ito T, Ueha S, Inadera H, Matsushima K:Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells. Toxicol Sci. 2004, 81: 139-147.

Tokunaga N, Nagaya N, Shirai M, Tanaka E, Ishibashi-Ueda H, Harada-Shiba M, Kanda M, Ito T, Shimizu W, Tabata Y, Uematsu M, Nishigami K, Sano S, Kangawa K, Mori H:Adrenomedullin gene transfer induces therapeutic angiogenesis in a rabbit model of chronic hind limb ischemia: benefits of a novel nonviral vector, gelatin. Circulation.2004, 109: 526-531.

Nagaya N, Yamamoto H, Uematsu M, Itoh T, Nakagawa K, Miyazawa T, Kangawa K, Miyatake K:Green tea reverses endothelial dysfunction in healthy smokers. Heart.2004, 90: 1485-1486.

Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura S:Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. 2004, 287: H2670-2676.

Okumura H, Nagaya N, Itoh T, Okano I, Hino J, Mori K, Tsukamoto Y, Ishibashi-Ueda H, Miwa S, Tambara K, Toyokuni S, Yutani C, Kangawa K:Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt- dependent pathway. Circulation. 2004, 109: 242-248.

Arao T, Fukumoto H, Takeda M, Tamura T, Saijo N, Nishio K:Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474. Cancer Res. 2004, 64: 9101-9104.

Matsumoto M, Kokame K, Soejima K, Miura M, Hayashi S, Fujii Y, Iwai A, Ito E, Tsuji Y, Takeda-Shitaka M, Iwadate M, Umeyama H, Yagi H, Ishizashi H, Banno F, Nakagaki T, Miyata T, Fujimura Y:Molecular characterization of ADAMTS13 gene mutations in japanese patients with upshaw-schulman syndrome. Blood. 2004, 103:1305-1310.

Matsumoto M, Yagi H, Ishizashi H, Wada H, Fujimura Y:The Japanese experience with TTP/ HUS. Semin Hematol. 2004, 41: 68-74.



Kasahara K, Fukuoka K, Konishi M, Hamada K, Maeda K, Mikasa K, Kimura H:Two cases of endobronchial neurilemmoma and review of the literature in japan. Intern Med. 2003, 42:1215-1218.

Takahashi K, Kita E, Konishi M, Yoshimoto E, Mikasa K, Narita N, Kimura H:Translocation model of candida albicans in DBA-2/J mice with protein calorie malnutrition mimics hematogenous candidiasis in humans. MicrobPathog. 2003, 35: 179-187.

Izumizaki M, Tamaki M, Suzuki Y, Iwase M, Shirasawa T, Homma I, Kimura H:The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemo-globinopathy. Am J Physiol Regul Integr Comp Physiol. 2003, 285: R747-753.

Suda A, Takiguchi Y, Omori S, Miyazawa H, Sugimoto T, Kurosu K, Tatsumi K, Tanabe N, Kuriyama T, Hiroshima K, Kimura H:Gene delivery to the lung by means of syngeneic fibroblasts: an experimental model. Exp Lung Res. 2003, 29: 227-241.

Fukuoka K, Nakano Y, Nakajima A, Hontsu S, Kimura H:Endobronchial lesions involved in mycobacterium avium infection. Respir Med. 2003, 97: 1261-1264.

Hida W, Okabe S, Tatsumi K, Kimura H, Tsuneto A, Chin K, Ohi M, Nakayama H, Satoh M, Kuriyama T:Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome. Sleep and Breathing. 2003, 7: 3-12.

Hamada K, Suzaki Y, Goldman A, Ning YY, Goldsmith C, Palecanda A, Coull B, Hubeau C, Kobzik L:Allergen-independent maternal transmission of asthma susceptibility. J Immunol. 2003, 170: 1683-1689.



Omori S, Takiguchi Y, Suda A, Sugimoto T, Miyazawa H, Takiguchi Y, Tanabe N, Tatsumi K, Kimura H, Pardington PE, Chen F, Chen DJ, Kuriyama T:Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair (Amst). 2002, 1:299-310.

Hasako K, Masuyama S, Mizoo A, Kojima A, Kimura H, Kuriyama T:The effect of changing rate of PIO2 fall on relationship between ventilatory and heart rate response to progressive hypoxia. Jpn J Appl Phys. 2002,32:35-42.

Omori S, Takiguchi Y, Hiroshima K, Tanabe N, Tatsumi K, Kimura H, Nagao K, Kuriyama T:Peripheral pulmonary diseases: evaluation with endobronchial US initial experience. Radiology. 2002, 224:603-608.

Watanabe A, Kawabata Y, Okada O, Tanabe N, Kimura H, Hatamochi A, Shinkai H, Sakai N, Shimada T, Hiroshima K, Kuriyama T:Ehlers-Danlos syndrome type IV with few extrathoracic findings: a newly recognized point mutation in the col3A1 gene. Eur Respir J. 2002, 19: 195-198.



Yoshikawa M, Yoneda T, Takenaka H, Fukuoka A, Okamoto Y, Narita N, Nezu K:Distribution of muscle mass and maximal exercise performance in patients with COPD. Chest. 2001;119:93-98.

Nezu K, Kawaguchi T, Kimura M, Yasukawa M, Kushibe K, Taniguchi S, Yoshikawa M: Lung volume reduction surgery and nutritional status in patients with severe emphysema. Jpn J Thorac Cardiovasc Surg. 2001;49:552-556.

Nezu K, Yoshikawa M, Yoneda T, Kushibe K, Kawaguchi T, Kimura M, Kobayashi A, Takenaka H, Fukuoka A, Narita N, Taniguchi S:The effect of nutritional status on morbidity in COPD patients undergoing bilateral lung reduction surgery. Thorac Cardiov Surg. 2001;49:216-220.

Yoneda T, Yoshikawa M, Fu A, Tsukaguchi K, Okamoto Y, Takenaka H:Plasma levels of amino acids and hypermetabolism in patients with chronic obstructive pulmonary disease. Nutrition. 2001;17:95-99.

Itakura M, Tokuda A, Kimura H, Nagai S, Yoneyama H, Onai N, Ishikawa S, Kuriyama T, Matsushima K:Blockade of secondary lymphoid tissue chemokine exacerbates Propioni bacterium acnes-induced acute lung inflammation. J Immunol. 2001, 166:2071-2079.

Abe Y, Tatsumi K, Sugito K, Ikeda Y, Kimura H, Kuriyama T:Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension. J Cardiovasc Pharmacol. 2001, 37: 239- 351.

Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Hiroshima K, Inadera H, Matsushima K, Kuriyama T:Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2001, 164:319-324.

Takiguchi Y, Uruma T, Hiroshima K, Motoori K, Watanabe R, Hamaoka T, Okada O, Kimura H, Kuriyama T:Stable pulmonary capillary haemangiomatosis without symptomatic pulmonary hypertension. Thorax. 2001, 56:815-817.